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Investigating RAS Signaling in Cancer

Quantitative Proteomics methods developed by CPTAC have been enlisted in developing analytical tools to study the oncogene RAS and its related pathways.

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Clinical Proteomic Tumor Analysis Consortium

The National Cancer Institute (NCI), part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium (CPTAC) in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. Read more.  

Selected Publications

  • Xu Z, Wu C, Xie F, Slysz GW, Tolić N, Monroe ME, Petyuk VA, Payne SH, Fujimoto GM, Moore RJ, Fillmore TL, Schepmoes AA, Levine DA, Townsend RR, Davies SR, Li S, Ellis M, Boja E, Rivers R, Rodriguez H, Rodland KD, Liu T, Smith RD. (2014) Comprehensive Quantitative Analysis of Ovarian and Breast Cancer Tumor Peptidomes. J Proteome Res. Epub ahead of print . View PubMed abstract..
  • Yang J, Gupta V, Carroll KS, Liebler DC. (2014) Site-specific mapping and quantification of protein S-sulphenylation in cells. Nat Commun. 5 1-12. View PubMed Abstract.
  • Sharma V, Eckels J, Taylor GK, Shulman NJ, Stergachis AB, Joyner SA, Yan P, Whiteaker JR, Halusa GN, Schilling B, Gibson BW, Colangelo CM, Paulovich AG, Carr SA, Jaffe JD, MacCoss MJ, MacLean B. (2014) Panorama: a targeted proteomics knowledge base. J Proteome Res. 13 (9): 4205-10. View PubMed Abstract.

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