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First Large-Scale Proteogenomic Study of Breast Cancer Provides Insight into Potential Therapeutic Targets

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Clinical Proteomic Tumor Analysis Consortium

The National Cancer Institute (NCI), part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium (CPTAC) in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. Read more.  

Selected Publications

  • Mertins P, et al (2016) Proteogenomic Analysis of Human Breast Cancer Connects Genetic Alterations to Phosphorylation Networks Nature . http://www.nature.com/nature.
  • Xu Z, Wu C, Xie F, Slysz GW, Tolić N, Monroe ME, Petyuk VA, Payne SH, Fujimoto GM, Moore RJ, Fillmore TL, Schepmoes AA, Levine DA, Townsend RR, Davies SR, Li S, Ellis M, Boja E, Rivers R, Rodriguez H, Rodland KD, Liu T, Smith RD. (2014) Comprehensive Quantitative Analysis of Ovarian and Breast Cancer Tumor Peptidomes. J Proteome Res. Epub ahead of print . View PubMed abstract..
  • Yang J, Gupta V, Carroll KS, Liebler DC. (2014) Site-specific mapping and quantification of protein S-sulphenylation in cells. Nat Commun. 5 1-12. View PubMed Abstract.

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