The Office of Cancer Clinical Proteomics Research (OCCPR) is committed to providing the media with timely and accurate information. This section offers key resources for patients, cancer researchers, physicians, and media professionals.
NCI OCCPR Webinar: Advances In MS-based Single-cell Proteomics
Tuesday, January 19th, 2021
Dr. Tao Liu, Pacific Northwest National Laboratory
Mass spectrometry-based proteomics enables the characterization of human proteome at a genome scale. Recent advances in sample handling platforms and proteomic analysis strategies also allow for analysis of protein expression and phosphorylation in very small populations of cells, even single cells. These advances in single-cell proteomics holds great potential for improved understanding of biological heterogeneity underlying cancer for translational applications.
NCI OCCPR Webinar: MSFragger
Wednesday, July 15th, 2020
Dr Alexey Nesvizhskii, Professor of Computational Medicine and Bioinformatics & Pathology, University of Michigan
This webinar will demonstrate how to effectively use the ultrafast MSFragger database search tool, developed in 2017, to comprehensively identify peptides. Dr Nesvizhskii will show how to quickly perform open searches for datasets containing millions of mass spectrometry spectra and analyze large-scale, unbiased detection of post-translational modifications.
NCI OCCPR Webinar: LinkedOmics
Thursday, June 18, 2020
Dr. Eric Jaehnig, Research Associate at Baylor College of Medicine
This webinar will provide a brief overview of the LinkedOmics software developed in the Bing Zhang lab at Baylor University. Dr. Eric Jaehnig shows participants how to use the tool to explore associations between multiple types of omics datasets.
NCI OCCPR Webinar: Network Exploration Tools
Thursday, April 9, 2020
Zeynep Gumus, Ph.D., Assistant Professor, Department of Genetics and Genomics Sciences, Ichan School of Medicine at Mt. Sinai, New York
Selim Kalayci, Ph.D., Postdoctoral Research Fellow, Department of Genetics and Genomics Sciences, Ichan School of Medicine at Mt. Sinai, New York
This webinar will provide a brief overview of the CPTAC Network Exploration Tool ProNetView by Selim Kalayci, Ph.D. in Zeynep Gumus, Ph.D.’s group. The speaker shows participants how to use the three-dimensional tool to explore novel interactions within the context of a specific cancer type.
Principles of Proteomics Series: Bioinformatics
Friday, March 27, 2020
Dr. Bing Zhang of the CPTAC program and Baylor College of Medicine discusses bioinformatics.
Principles of Proteomics Series: Post-translational Modifications
Friday, March 27, 2020
Dr. Steven Carr of the CPTAC program and the Broad Institute of Harvard and MIT discusses post-translational modifications
OCCPR Webinar Series: The Cancer Imaging Archive
Wednesday March 18th, 2020
Mr. Justin Kirby, Technical Director, TCIA
This webinar will provide a brief overview of NCI’s The Cancer Imaging Archive (TCIA)/Clinical Proteomics Tumor Analysis Consortium (CPTAC) imaging database, by Mr. Justin Kirby, Technical Director at TCIA. Mr. Kirby will demonstrate how to navigate the TCIA-CPTAC website for over 6000 images for more than 1500 radiology and histopathology cases associated with the CPTAC proteomic datasets found in the Proteomic Data Commons and its complementary genomic data found at the Genomics Data Commons database.
NCI OCCPR Webinar: Heatmap Visualization Tools
Thursday, February 6, 2020
Anna Calinawan, Biomedical Software Engineer, Ichan School of Medicine at Mt. Sinai, New York
This webinar will provide a brief overview of the CPTAC Heatmap Visualization Tool ProTrack by Anna Calinawan in Pei Wang, Ph.D.’s group, ccrcc.cptac-data-view.org. The speaker shows participants how to explore the tool and query for gene and protein expression.
NCI OCCPR Webinar: NCI Antibody Program
Wednesday, January 22, 2020
Dr. Tara Hiltke, Ph.D., NCI OCCPR, Program Director
This webinar that will provide a brief overview of NCI’s Antibody Portal by Dr. Tara Hiltke. Dr. Hiltke talks about the antibody program, shows participants how to navigate the newly re-vamped portal, as well as discusses the "Request For Target" antibody submission requirements through the NCI Antibody Characterization Program.
Principles of Proteomics Series: Proteogenomics
Friday, December 20, 2019
Dr. Pei Wang of the CPTAC program and Ichan School of Medicine discusses proteogenomics.
Principles of Proteomics Series: Mass Spectrometry
Friday, December 20, 2019
Dr. Amanda Paulovich of the CPTAC program and the Fred Hutchinson Cancer Research Center discusses mass spectrometry
NCI OCCPR Webinar: Proteomic Assay Portal:
Wednesday, December 11, 2019
Dr. Mehdi Mesri, Ph.D., NCI OCCPR, Program Director
Dr. Karen Ketchum, Ph.D., Director of Strategic Solutions, ESAC Inc.
Dr. Jeffery Whiteaker, Ph.D., Fred Hutchinson Cancer Research Laboratory
This webinar that will provide a brief overview of NCI’s Proteomic (CPTAC) Assay Portal by Drs. Mehdi Mesri, Karen Ketchum (ESAC, Inc) and Jeffery Whiteaker (Fred Hutchinson Cancer Research Laboratory). With more than 2,300 proteomic assays available on the Portal, designed and optimized for mass spectroscopy, the speakers talk about the Assay Program, show participants how to navigate the website, as well as discuss assay submission. The speakers also talk about the Clinical Proteomic Tumor Analysis Consortium CPTAC experimental guidelines that ensure that publicly available proteomic assays meet the Consortium’s rigor and reproducibility standards.
NCI OCCPR Webinar: Proteomic Data Commons
Wednesday, November 13, 2019
Dr. Chris Kinsinger, Ph.D., NCI OCCPR, Program Director
Dr. Rajesh Thangudu, Ph.D., Bioinformatic Scientist, ESAC Inc.
This webinar will provide a brief overview of NCI’s Proteomic Data Commons (PDC) by Drs. Chris Kinsinger and Ratna Rajesh Thangudu. The speakers show participants how to navigate the website as well as submit data.
International Cancer Proteogenome Consortium
Wednesday, September 19, 2018
Learn about ICPC and how the consortium is breaking down silos to advance proteogenomic cancer research worldwide.
Perspectives in Proteomics: Interview with Dr. Henry Rodriguez
Friday, May 4, 2018
Dr. Henry Rodriguez discusses the future of proteogenomics, precision medicine, and open data in cancer research at the Human Proteome Organization World Congress (HUPO2017).
Dr. Henry Rodriguez – Introduction of Joe Biden at HUPO2017 Global Leadership Gala
Saturday, September 16, 2017
Dr. Henry Rodriguez gives introduction of keynote speaker, 47th VP of the United States Joseph R. Biden Jr., at the HUPO2017 Global Leadership Gala. View Video.
47th VP of the United States Joseph R. Biden Jr. Speech at HUPO2017 Global Leadership Gala
Saturday, September 16, 2017
Keynote speech given by the 47th Vice President of the United States of America Joseph R. Biden Jr. at the HUPO2017 Global Leadership Gala. Inspired by the efforts of the Cancer MoonshotSM initiative, the event raised awareness of HUPO and its activities, advances in proteomics and its impact on human health, and the National Cancer Institute’s (NCI) International Cancer Proteogenome Consortium (ICPC) for pledging to share cancer-related proteogenomic and imaging data hosted by NCI with researchers worldwide. View Video.
Proteogenomics Research – On the Frontier of Precision Medicine
Thursday, September 14, 2017
Learn about cancer genomics, how it is being integrated with proteomics (termed proteogenomics), and how proteogenomics is anticipated to improve precision medicine. Watch in traditional and simplified Chinese.
Dr. Henry Rodriguez - Proteogenomics in Cancer Medicine
Wednesday, July 5, 2017
Dr. Henry Rodriguez speaks with ecancer television at WIN 2017 about the integration of genomic and proteomic information (proteogenomics) in a patient's tumor into a map for druggable targets. He also highlights aspects of the Cancer MoonshotSM initiative, working with the National Cancer Institute, which aim to open global access to data libraries of tumor genomics and proteomics, including the APOLLO program and the International Cancer Proteogenome Consortium.
Controlling for variables
Wednesday, May 17, 2017
Dr. Amanda Paulovich, a member of the Fred Hutch Clinical Research Division, was motivated by an "ethical dilemma" to research how proteins affect the way cancer patients react to cancer drugs. View Video
Mapping Proteins in Cancer/ Cell, June 29, 2016 (Vol. 166, Issue 3)
Wednesday, Jun 29, 2016
Dr. Karin Rodland and her colleagues from Pacific Northwest National Laboratory mapped all proteins (proteomics) in ovarian cancer patients, compared them with proteins from normal tissues, and proposed potential therapeutic strategies to better target cancer. Check out the paper at (click here). View Video
PODCAST: Dr. Warren Kibbe & Dr. Henry Rodriguez: Working toward a cure for cancer
October 12, 2016
The Obama administration's cancer moonshot has brought three Federal agencies together - the National Cancer Institute (NCI), the Department of Defense (DoD), and the Department of Veterans Affairs (VA), using state-of-the-art research methods in proteogenomics to more rapidly identify unique targets and pathways of cancer for detection and intervention. Dr. Henry Rodriguez, director of Proteogenomics Research, and Dr. Warren Kibbe, director of the Center for Biomedical Informatics and Information Technology at NCI, join Federal Drive with Tom Temin to discuss what the Institute is bringing to the Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) network.
PODCAST: From Lost in Translation to Paradise Found: Enabling Protein Biomarker Method Transfer by Mass Spectrometry
October 7, 2014
Translation of novel biomarkers into clinical care for the evaluation of therapeutic safety and efficacy has been slow, partly attributable to the cost and complexity of immunoassay development. The potential for liquid chromatography-tandem mass spectrometry (LC-MS/MS) to streamline the translation of novel protein biomarkers is profound. Drs. Henry Rodriguez and Andrew Hoofnagle discuss what the future may be for clinical proteomics. This is an American Association for Clinical Chemistry (AACC) podcast. To listen, click here.
PODCAST: The Journey to Regulation of Protein-Based Multiplex Quantitative Assays
April 22, 2011
Drs. Emily Boja and Henry Rodriguez provide insight into what are the key issues and questions that must be addressed in moving proteomic biological analytes and platforms from research to cleared FDA test. This is an American Association for Clinical Chemistry (AACC) podcast. To listen, click here.
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