In the special December issue of Proteomics Clinical Applications , two articles focus directly on scientific outputs from CPTC. A Viewpoint article, authored by Participants of a Wellcome Trust/EBI meeting and retreat (Patterson et al.), advocate the leveraging of the mock 510 (k) documents developed by CPTC for further development in order to better understand regulatory need. Additionally, experts from the CPTC program office (Rodriguez et al.) wrote a comprehensive review highlighting the introduction of multiplexed multiple reaction monitoring mass spectrometry into the biomarker pipeline developed by CPTC investigators. These articles can be found here.