News and Announcements

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Even More CPTAC Pathology Images Available!

...And there's more!!!  Another new batch of CPTAC histopathology imaging data has been released and is now publicly available on the TCIA CPTAC Pathology Portal.


CPTAC Researchers Associate High Immune Checkpoint Components and Immune Tolerance with Poor Clinical Outcomes in Luminal B Breast Cancer

As part of NIH’s mission for collaboration and team science, Dr. Matthew Ellis, Co-Principal Investigator of the CPTAC Proteogenomic Translational Research Center and Dr.


OCCPR Webinar: Proteomic Assay Portal

Did you know about NCI’s Proteomic (CPTAC) Assay Portal?  It’s a free resource for biological scientists performing mass spectroscopy.  The portal houses more than 2300 fit-for-purpose, proteomic assays designed and optimized for anyone to use.   Each assay is validated using CPTAC experimental g


The CPTAC Pathology Portal Has New Images

A new batch of CPTAC histopathology imaging data has been released and is now publicly available on the TCIA CPTAC Pathology Portal.

The TCIA quarterly report lists the addition of 76 new pathology slides and 25 new pathology subjects for the cutaneous melanoma, glioblastoma multiforme, and sarcoma tumor types.

TCIA has partnered with CPTAC to host both the radiology and pathology imaging data generated by the CPTAC Program.  Imaging data is available for 10 cancer types including AML, clear cell renal cell carcinoma, head & neck squamous cell carcinoma, lung squamous cell...


GDC Releases Harmonized Genomic Data From CPTAC

Data Release-20 from the Genomic Data Commons (GDC) includes genomics from a new CPTAC project!  

The CPTAC Proteogenomic Confirmatory Study examined prospectively collected colon, breast and ovarian tumors for analysis, including harmonized whole exome sequencing, RNA-Seq, and miRNA-Seq that is now available.  Complimentary proteomic and phosphoproteomic analysis can also be found on the CPTAC Data Portal and the Proteomic Data Commons (PDC).

CPTAC has provided the Genomic Data Commons (GDC) with genomic data from over 600 cancer patients with diverse disease types including...


CPTAC Researchers Reveal Novel Biological Features of Kidney Clear Cell Carcinoma

Investigators with the Clinical Proteomic Tumor Analysis Consortium (CPTAC) have generated the most comprehensive multi-omics dataset for clear cell renal cell carcinoma (ccRCC), the most commonly diagnosed kidney cancer subtype. The investigators used integrative proteogenomics, to reveal new insights into kidney cancer.


CPTAC Scientific Symposium 2019 – Great Beginnings!

Over three hundred proteomic explorers and  Clinical Proteomics Tumor Analysis Consortium (CPTAC) participants from around the country convened on the NIH Bethesda campus to share cutting-edge proteogenomic research in the first ever, public-facing CPTAC Scientific Symposium.


One Computational Step in the Journey to Identify Biological Pathways in Cancer

Large multi-omics datasets are becoming increasingly popular for studying biological systems including the identification of biological pathways, or more broadly defined gene sets, that are associated with certain biological or clinical features of interest.


ICPC China Team Comprehensively Characterizes HBV Related Liver Cancer

Hepatocellular carcinoma (HCC), the most common form of liver cancer, occurs most often in people with hepatitis B or C viral (HBV or HCV) infections who drink large amounts of alcohol.  Unlike the recent progress of antiviral-eliminating therapy for HCV, current antiviral therapy is only able to reduce rather than eliminate HBV and is estimated to affect 292 million peop


CPTAC Teams Up With UniProt!

UniProt, the leading online protein reference library, has teamed up with CPTAC!  Now, search results for your protein-of-interest will include links to the CPTAC Assay Portal for relevant peptides and assay protocols, while giving CPTAC users all the rich functional annotation in UniProt!  


CPTAC Researchers Develop Novel RAS-Antibodies for the Cancer Research Community through the NCI RAS-Initiative

RAS gene mutations and their pathways have  stymied cancer researchers for decades.  RAS-driven cancers make up more than 30% of all human cancers due to their association with uncontrollable cell growth, death-signal evasion, and drug resistance.  In 2014, the National Cancer Institu


cBioPortal Gets a New Addition: CPTAC Researchers Integrate Mass-Spectrometry Data Into Genomic Platform

Genomics platform cBioPortal offers a “biologist-friendly” resource for querying mutations, copy number variations and gene expression. It contains data from The Cancer Genome Atlas (TCGA) which includes proteomics data in the form of arrays that use antibodies to track protein levels. CPTAC mass spectrometry-based proteomics, however, has more information than the arrays provide.


Multi-Omics Data Integration Special Issue Features Research from CPTAC Investigators

The Journal of Molecular & Cellular Proteomics has released a special issue this month (August 2019) on Multi-Omics Integration.  The issue sets out to show how multi-omics research is integral to the understanding of biological systems.  It touts work from several of our CPTAC investigators who share their cutting


More Validated Targeted MS-based Assays Released on the NCI Proteomics Assay Portal!

New assays have been released today!  CPTAC and researchers from the University of Victoria – Genome British Columbia Proteomics Centre just released over 130 quantitative, fit-for-purpose, multiplexed mouse multiple reaction monitoring (MRM) mass spectrometry (MS)-based  plasma assays for public use on NCI’s Proteomic (CPTAC) Assay Portal


CPTAC Researchers Develop New Technique for Mapping the O-Glycoproteome

CPTAC researchers at John Hopkins University School of Medicine have developed a technique to reliably identify o-linked glycosylation sites and site-specific glycans with core 1 structures.  Before you dust off


Low Cell Input? No Problem! CPTAC Researchers Develop Low Sample Input Proteomics Protocol

Proteomic profiling often entails using a large sample input to explore the dynamic nature of protein expression and regulation. However, there are instances when researchers have the opposite due to prior methodology such as fluorescence activated cell sorting (FACS) or when dealing with patient samples.


Amsterdam UMC Joins the ICPC

June 13th, 2019 marked the addition of our 33rd institution to the International Cancer Proteogenomic Consortium (ICPC).  We are pleased to include Amsterdam UMC as a participant in the global effort to accelerate cancer research.


The National Cancer Center - Korea (NCC-K) Joins the International Cancer Proteogenomic Consortium (ICPC)

The National Cancer Center - Korea (NCC-K) joins the International Cancer Proteogenome Consortium (ICPC) global partnership.  The NCC-K has joined the ranks of 31 institutions in 12 countries around the world that have previously made this commitment with the


Proteomic Dataset Release of the CPTAC and CBTTC Collaborative Pediatric Brain Tumor Pilot Study

While it’s a common misconception that all tumors in the brain are the same, there are more than 120 subtypes of brain cancers with very diverse features and diagnosis.


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