A new pan-cancer study from the National Institute of Health’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) explores how inherited genetic variants shape protein function in cancer. Using a method called precision peptidomics, CPTAC researchers mapped over 337,000 coding germline variants to peptides detected in tumor samples and normal adjacent tissues across ten cancer types. Their work, published in Cell, has revealed how these variants might alter protein structure, allele-specific expression, post-translational modifications, and ultimately contribute to oncogenesis…