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News and Announcements

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Lung Adenocarcinoma (LUAD) Discoveries from two NCI Proteomics Consortia

Two new studies released July 9th, 2020 in Cell unravel the biology of lung adenocarcinoma (LUAD) using a suite of molecular techniques that, combined, provide a more complete picture of the disease than ever before.


OCCPR Webinar: MSFragger

Join Dr. Alexey Nesvizhskii, Professor of Pathology and Computational Medicine & Bioinformatics at University of Michigan, as he speaks on our next OCCPR Webinar about his ultrafast MSFragger software.  The webinar will take place on Wednesday, July 15th at 1pm - registration is free, but required.


In Case You Missed It: CPTAC Investigator Spotlight on Karin Rodland

The Investigator Spotlight Series was the brain child of Dr. Dawn Hayward, an NCI Communications Fellow at OCCPR, to highlight our CPTAC researchers and thier work.  In case you missed it the first time, here she features CPTAC scientist Dr. Karin Rodland.  Enjoy!


CPTAC At AACR Virtual Meeting II

We are so excited to be a part of the AACR Virtual Meeting II, June 22-24, 2020


Proteomics 3 Ways – An Efficient Analysis of Global, Glyco-, and Phospho-Proteomics

In a new study published in Analytical Chemistry, we see another example of ingenuity by NCI’s Office of Cancer Clinical Proteomic Research (OCCPR) Clinical Proteomic Tumor Analysis Consortium (CPTAC) scientists.  In an effort to optimize analytical output and conserve hard-to-obtain biospecimen samples, CPTAC researchers out of John Hopkins School of Medicine


Joint Proteomic and Genomic Data Release for Head and Neck Squamous Cell Carcinoma

108 cases of the NCI’s Clinical Proteomic Tumor Analysis Program (CPTAC) Head and Neck Squamous Cell Carcinoma Discovery Study have been proteomically and genomically profiled!  Each case includes HPV-negative, treatment naive and normal adjacent tissue, and includes proteomic ad phosphoproteomic data on the Proteomic Data Commons (PDC), as well as RNA-Seq, miRNA-Seq, WGS, WXS genomic data on the


50 New AML Pathology Slides on TCIA-CPTAC Pathology Portal

50 new pathology slides from 33 new Acute Myeloid Leukemia (AML) subjects are now available on the TCIA-CPTAC Pathology Portal. The April 2020 image release brings the total number of AML pathology slides to 120 from 88 subjects, with most of them also having both tumor blood and marrow imaging. 


OCCPR Webinar: LinkedOmics

Scientists from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) program developed a powerful tool to explore associations between multiple types of omics datasets.  The LinkedOmics software collects genomic, transcriptomic and proteomic datasets from


CPTAC Researchers Identify New Features of Ovarian High-Grade Serous Cancer Associated with Patient Survival Rates and Alternative Drug Therapies

In a study published on April 21, in Cell Reports Medicine, researchers with the National Cancer Institutes’ (NCI) Clinical Proteomics Tumor Analysis Consortium (CPTAC) take a comprehensive look at the root causes of ovarian high-grade serous carcinoma (HGSC).  Through integrated proteomic and genomic an


150 New Assays on the NCI Assay Portal!

One of the missions of theClinical Proteomic Tumor Analysis Consortium (CPTAC) is to provide proteomic resources to the greater scientific community.  So, we have great news to announce!  CPTAC has added 150 "fit-for-purpose," multiplexed, mass spectrometry-based proteomic targeted assays to its Assay Portal!


New Quarterly Release of CPTAC Radiology Imaging Data Available

It’s that time again!  CPTAC radiology images have been released on the TCIA CPTAC Pathology Portal!  Between conference calls and literature searches, take a look at the 38 new radiology and 8 new pathology images added to Portal – all for free!


OCCPR Webinar: Network Exploration Tool for Cancer Research

Finding novel interactions from comprehensive genomics and proteomics (mass spectrometry generated) is made significantly easier with the help of a visual, interactive guide.


The Proteomic Data Commons Is Now Live!

NCI announces the launch of the NCI Proteomic Data Commons (PDC)!


New CPTAC Imaging Data Available

New histopathology slides available from CPTAC lung squamous cell carcinoma, lung adenocarcinoma and glioblastoma multiforme studies. 149 images from 28 new cases added in the month of February 2020 are publicly available on the TCIA CPTAC Pathology Portal!


Making Space for Ubiquitin Proteomics

Protein ubiquitylation is best known for its role in degradation, leading molecules to the cell’s recycle bin, but it also has roles in cellular processing and protein interactions.  Unfortunately, research using proteomic techniques have been limited due to experimental and technical complications.    


OCCPR Webinar: The Cancer Imaging Archive

The Cancer Imaging Archive (TCIA) houses radiology and histopathology data for the CPTAC Program.  There are over 1500 cases and with more than 6000 images…and counting…of 10 cancer types freely available for the public to view.  Each case has complementary proteomic data through the Proteomic Data Commons and genomic data through the


New, Detailed Molecular Roadmap Boosts Fight Against Endometrial Cancer

After 12 million measurements, new drug targets emerge


CPTAC Survey Results Show Success

The Office of Cancer Clinical Proteomics Research (OCCPR) cares what you think about the Clinical Proteomic Tumor Analysis Consortium (CPTAC) program and all its offerings! Working with Clarivate Analytics to conduct a survey, we wanted to determine the effect of the CPTAC program on the proteogenomic research community.  The evaluation provided the NCI with an objective, third-party assessment of CPTAC program implementation.


New CPTAC Histopathology Imaging Data Ready to View

The addition of 367 new pathology slides and 51 new pathology subjects for lung squamous cell carcinoma is now available on the TCIA CPTAC Pathology Portal.  Additional imaging data is also available for 10 cancer types including cutaneous melanoma, clear cell renal cell carcinoma, head & neck squamous cell carcinoma, glioblastoma multiforme, lung adenocarcinoma


OCCPR Webinar: Heatmap Visualization Tool for Cancer Research

Visualizing gene and protein expression from comprehensive genomics and proteomics (mass spectrometry generated) data is beneficial for researchers but often difficult to achieve. Researchers from the Mount Sinai PGDAC team within the CPTAC program have developed a new interactive data tool to query genes and proteins of interest in a visual format.


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