Large multi-omics datasets are becoming increasingly popular for studying biological systems including the identification of biological pathways, or more broadly defined gene sets, that are associated with certain biological or clinical features of interest.
Hepatocellular carcinoma (HCC), the most common form of liver cancer, occurs most often in people with hepatitis B or C viral (HBV or HCV) infections who drink large amounts of alcohol. Unlike the recent progress of antiviral-eliminating therapy for HCV, current antiviral therapy is only able to...
UniProt, the leading online protein reference library, has teamed up with CPTAC! Now, search results for your protein-of-interest will include links to the CPTAC Assay Portal for relevant peptides and assay protocols, while giving CPTAC users all the rich functional annotation in UniProt...
RAS gene mutations and their pathways have stymied cancer researchers for decades. RAS-driven cancers make up more than 30% of all human cancers due to their association with uncontrollable cell growth, death-signal evasion, and drug resistance. In 2014, the National Cancer Institu
Genomics platform cBioPortal offers a “biologist-friendly” resource for querying mutations, copy number variations and gene expression. It contains data from The Cancer Genome Atlas (TCGA) which includes proteomics data in the form of arrays that use antibodies to track protein levels. CPTAC mass...
The Journal of Molecular & Cellular Proteomics has released a special issue this month (August 2019) on Multi-Omics Integration. The issue sets out to show how multi-omics research is integral to the understanding of biological systems. It touts work from several of our CPTAC investigators...
New assays have been released today! CPTAC and researchers from the University of Victoria – Genome British Columbia Proteomics Centre just released over 130 quantitative, fit-for-purpose, multiplexed mouse multiple reaction monitoring (MRM) mass spectrometry (MS)-based plasma assays for public...
CPTAC researchers at John Hopkins University School of Medicine have developed a technique to reliably identify o-linked glycosylation sites and site-specific glycans with core 1 structures. Before you dust off
Proteomic profiling often entails using a large sample input to explore the dynamic nature of protein expression and regulation. However, there are instances when researchers have the opposite due to prior methodology such as fluorescence activated cell sorting (FACS) or when dealing with patient...
June 13th, 2019 marked the addition of our 33rd institution to the International Cancer Proteogenomic Consortium (ICPC). We are pleased to include Amsterdam UMC as a participant in the global effort to accelerate cancer research.
The National Cancer Center - Korea (NCC-K) joins the International Cancer Proteogenome Consortium (ICPC) global partnership. The NCC-K has joined the ranks of 31 institutions in 12 countries around the world that have previously made this commitment with the
While it’s a common misconception that all tumors in the brain are the same, there are more than 120 subtypes of brain cancers with very diverse features and diagnosis.
Dr. Henry Rodriguez gave the keynote address at the 62nd Annual Meeting of the Japanese Society of Nephrology in Nagoya, Japan this week. In line with the conference’s theme Open The Future, Dr.
Since its first mention in the scientific literature in 2004 by Jaffe et al1, the term proteogenomics has been shrouded in mystery and thick technical language. It is a complex idea, but one that is gaining traction as its value to improve our understanding of cancer development and potentially...
Phosphorylation is a key process in the regulation of protein activity and has long been appreciated as an essential mechanism for the control of cellular function - tells a protein where to go, what to bind to and even when to die.
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) is pleased to release its newest comprehensive dataset - deep proteomic/phosphoproteomic data and imaging data of Lung Adenocarcinoma (LUAD) patient tumors. The CPTAC Tumor Characterization Program uses proteogenomic analysis to systematic...
Riding the wave of the future requires scientists to move away from silo-thinking to an inclusive and collaborative mind set. By leveraging the power of crowdsourcing, precisionFDA and NCI-CPTAC teamed up to launch the Multi-omics Enabled Sample Mislabeling Correction Big Data Challenge. Over 500...
Analyzing both the entire set of genes and all the proteins produced by colon cancer tissues from patient samples has revealed a more comprehensive view of the tumor that points at novel cancer biological mechanisms and possible new therapeutic strategies.
Is DNA sequencing enough to recommend personalized treatments for cancer patients? In a article published in Nature Reviews Clinical Oncology, CPTAC investigators and colleagues from the Fred Hutch, Baylor College of Medicine, and University of Washington Medicine make the case for proteogenomics...
CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer....