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News and Announcements

Harnessing Metabolomics with Jennifer Kyle, Ph.D.

The following is the seventh entry in a Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss metabolomics, collaboration, and the future of the field with Jennifer Kyle, PhD, a Staff Scientist at Pacific Northwest National Laboratory.…


CPTAC Assays Leveraged in Phase II Clinical Trial

A single-arm phase 2 clinical trial conducted by researchers from the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI), tested a new treatment approach for high-risk, resectable melanoma. The trial measured proteins with tests developed by the NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC)…


Resource Spotlight: The National Cancer Institute's Proteomic Data Commons

Large-scale datasets generated via high-throughput sequencing and multi-omics technologies are shaping how researchers uncover features of cancer biology. The National Cancer Institute's (NCI) Proteomic Data Commons (PDC), a component of the Cancer Research...


Boosting Throughput and Sensitivity in Single-Cell Proteomics by Leveraging Automated Workflows

Single-cell proteomics (SCP) is enabling researchers to understand cancer progression, immune response, developmental pathways, and more all at the cellular level. Historically, SCP has represented a considerable challenge for researchers due to low amounts of proteins within a single cell and the,...


Proteomic Data Commons Now Supports Metabolomics and Lipidomics Data

The National Cancer Institute's Proteomic Data Commons (PDC) launched in 2020, part of the National Cancer Institute's Cancer Research Data Commons (CRDC) data ecosystem, is the largest public repository of comprehensive tumor proteomic datasets, housing diverse data types such as proteome,...


IO-3 Assay Panel Offers Insights Into Immunotherapy Response

Cancer immunotherapies hold promise for inducing durable responses across cancer types, yet their effectiveness varies significantly among patients. In an effort to deepen our understanding of the mechanisms underlying response and resistance to immunotherapy, CPTAC researchers from the Fred...


Progress in Proteomics: Fernanda Martins Rodrigues, Ph.D.

The following is the sixth entry in a Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss bioinformatics, proteogenomics, and research ethics with Fernanda Martins Rodrigues, PhD, a post-doctoral research...


Illuminating Key Signaling Pathways and Tumor Evolution in High-Grade Glioma

Despite improvements in detection and therapy, the prognosis for high-grade glioma (HGG) remains poor. Prior research has studied disease progression in HGG, but our understanding of how and why the disease recurs so often (>90% of patients within two years for the most aggressive HGG) remains...


Pan-Cancer Analysis Identifies Promising Therapeutic Targets

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has performed proteogenomic characterization for over 1,000 primary tumors spanning 10 cancer types: breast invasive carcinoma (BRCA), clear cell renal cell carcinoma (CCRCC), colon adenocarcinoma (COAD), glioblastoma (GBM), head and neck...


Unveiling Glycoproteins with Tung-Shing Mamie Lih, Ph.D.

The following is the fifth entry in a Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss multiple facets of glycoproteomics research with Tung-Shing Mamie Lih, PhD, an associate researcher at Johns Hopkins...


Characterizing the Molecular Landscape of Rare Renal Cell Carcinomas

In a recent study aiming to address knowledge gaps in non-clear cell renal cell carcinoma (non-ccRCC), researchers from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted an integrated multi-omic analysis of 48 non-ccRCC cases along with a previously...


Driving Change in Cancer Research: Insights from Yifat Geffen

The following is the fourth entry in a Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss multiple facets of proteogenomics research with Yifat Geffen, PhD, a postdoctoral researcher at the Broad Institute of MIT...


Characterizing the Evolution of Glioblastoma

Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis despite advancements in treatment and diagnosis. Tumor recurrence, developing in most patients (>90%), poses a major challenge due to tumor heterogeneity and limited understanding of post-treatment evolution. Previous studies have...


Presenting our 2024 CPTAC Meritorious Posters

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) recently held its Scientific Investigator Meeting in Portland, Oregon at the Oregon Health & Science University campus. The meeting featured key scientific and programmatic updates spanning multiple cancer types presented by consortium...


Proteomics in Focus: Insights from Dr. Nicole Tignor

The following is the third entry in a new Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss multiple facets of proteomics research with Nicole Tignor, PhD, Assistant Professor at the Icahn School of Medicine at...


Proteogenomic Characterization of Small Cell Lung Cancer: A Pathway to Personalized Medicine

Small cell lung cancer (SCLC) is an aggressive form of lung malignancy with historically poor prognoses and limited options for targeted treatment. The low availability of suitable biospecimens has also hampered large molecular characterization efforts.


Deciphering the Tumor Microenvironment: A Proteogenomic Pan-Cancer Analysis

The tumor microenvironment (TME) is a complex network which plays a crucial role in cancer progression and treatment responses. In a recently published Pan Cancer analysis, the Clinical Proteomic Tumor Analysis...


Advancing Personalized Treatment Strategies for Patients with Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by the rapid proliferation of abnormal myeloid cells in the bone marrow and blood. AML is known for its heterogeneity, presenting challenges in treatment and predicting patient outcomes.


Excellence in Proteomics Research: A Conversation with Jeffrey Whiteaker

The following is the second entry in a new Q&A series highlighting selected Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers and their work. Join us as we discuss multiple facets of proteomics research with Jeffrey Whitaker, PhD, Director of Proteomics within the Paulovich Lab at...