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Displaying 21 - 40 of 273
Revolutionizing Liver Cancer Treatments: The Power of Organoid Models

Proteogenomic characterization of patient tissues has enriched our understanding of liver cancer, uncovering potential therapeutic targets, new subtypes, and offering hope for more effective treatments. However, there remains a gap in translating these findings into clinical practice.


The Cancer Imaging Archive Releases AI-Ready CPTAC Imaging Annotations to Facilitate Imaging-Omics Cancer Research

The Cancer Imaging Archive (TCIA), managed by the National Cancer Institute's Cancer Imaging Program (CIP), collects, curates, and hosts digital histopathology and standard-of-care radiology imaging from CPTAC-enrolled patients to provide data for imaging-omics research.    Algorithmic analysis of...


Illuminating Endometrial Carcinoma through Proteogenomics and Deep Learning

Recent strides in the field of genomics, exemplified by initiatives like The Cancer Genome Atlas (TCGA), have illuminated the genetic landscape of endometrial carcinoma (EC). The identification of four distinct EC...


Introducing a Suite of Pan-Cancer Multi-omic Papers from CPTAC

Researchers from the National Cancer Institute’s (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) have produced a resource of global proteomic and post-translational modifications, whole genome and whole exome sequencing, miRNA and totalRNA sequencing, DNA methylation, imaging, and clinical...


Novel 64-Protein Signature Predicts Treatment Response in High-Grade Serous Ovarian Cancer

In an effort recently published in Cell, CPTAC researchers aimed to identify patients with high-grade serous ovarian cancer (HGSOC) who may not respond to standard therapies. At present, there is no way...


PepQuery2: Empowering Proteomics Researchers with Ultrafast Data Analysis

Recently published in Nature Communications, PepQuery2 is a powerful tool that facilitates fast and targeted identification of both new and existing peptides in proteomics datasets obtained from mass spectrometry experiments. It...


ETH Zürich (Switzerland) and United States National Cancer Institute Sign Extension of MOU for Proteogenomics Cancer Research

The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the Switzerland International Cancer Proteogenome Consortium (ICPC) team at ETH Zürich are pleased to announce the formalization of an extension to their memorandum of understanding (MOU) for collaborative...


The MONTE Workflow: Enabling Deep Analysis of Sample-Limited Tissues

The limited availability of patient tissue samples poses a constant challenge for omics researchers, particularly in determining which analyses are feasible based on sample input requirements. Existing parallel workflows for multi-omic analyses have yielded valuable insights but are often restricted...


NCI Welcomes Renewed Commitments to the Cancer Moonshot with Taiwan

The United States National Cancer Institute (NCI) and Taiwan are pleased to announce the signing of an extension to their memoranda of understanding (MOUs) for proteogenomics cancer research with Academia Sinica and Chang Gung University. This extension marks a renewed commitment to the collaboration...


Integrated Glycoproteomic Characterization Reveals Molecular Features of ccRCC

Glycosylation is a ubiquitous type of protein modification that is associated with biological functions and diseases, including cancer. Often found on cell surface or secreted into circulation, glycoproteins can be leveraged for diagnosis and treatment.


Uncovering Cellular Architecture and Molecular Characteristics in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) is a common type of kidney cancer that originates from the cells of the renal tubules. Recent research has focused on identifying tumor-cell-specific markers to provide mechanistic insights into cancer etiology and support the development of novel targeted...


CPTAC Investigators Assess Coring and Laser Microdissection Techniques for Proteogenomic Analyses

Despite unprecedented advances in the development of targeted- and immuno-therapies for various cancer types, pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related death worldwide. A comprehensive characterization of PDAC is critical for the development of new therapies...


Paving the way for PDAC Precision Medicine

Despite extensive clinical and scientific efforts, pancreatic ductal adenocarcinoma (PDAC) remains one of the leading causes of cancer-related deaths in Korea and around the world. Prior analyses of PDAC tissues have identified key genomic features of the disease, but proteomic signatures have not...


CPTAC Assays Used to Analyze Aggressive Brain Tumors

Diffuse intrinsic pontine gliomas (DIPG) are a type of brain tumor that is extremely aggressive and have a historically poor prognosis. To improve these outcomes, the development of novel therapies and methods to measure their efficacy are critical.


APOLLO Researchers Uncover Novel Proteogenomic Features of Lung Cancer

The Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) network is a cancer...


CPTAC Researchers Molecularly Stratify Aggressive Histopathologic Subtypes of Kidney Cancer

Renal cell carcinoma (RCC) is among the ten most diagnosed cancers worldwide for men and women and comprises a wide array of histologically and genetically defined subtypes involving the kidney. Clear cell RCC (ccRCC) accounts for ~75% of all RCC cases and the majority of renal cancer-associated...


CPTAC Data Used to Develop Cutting Edge Tools for Illuminating the Druggable Genome

Recently, Dr. Bing Zhang and his team from the Lester and Sue Smith Breast Center at Baylor College of Medicine were awarded a two-year funding opportunity to develop Cutting Edge Informatics Tools for the NIH Common Fund program Illuminating the Druggable Genome (IDG).


CPTAC Researchers Document Differential Expression of Glycosylation Sites in Liver and Pancreatic Cancer

Core fucosylation (CF) of N-linked glycoproteins is linked with the functions of glycoproteins in many physiological and pathological processes. This feature has a high potential for use in the detection of cancer as well as the development of targeted therapies. For example, high levels of alpha-...


FDA and NIH Sign Memorandum of Understanding: Interagency Collaboration to Advance Proteogenomics Research

The National Cancer Institute (NCI) of the National Institutes of Health is pleased to announce the signing of a memorandum of understanding (MOU) bolstering its ongoing collaboration with the U.S. Food and Drug Administration (FDA). This MOU provides a framework that will enable and encourage the...


Ex Vivo Drug Sensitivity Testing in AML: Improving Response Predictability Using Proteomic Measurements

Genetic heterogeneity amongst leukemic cells is a major contributor to low survival rates and poor clinical outcomes for patients with acute myeloid leukemia (AML). This diversity drives complex signaling pathways at the protein level which necessitate individualized treatment protocols for each...


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