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Milestones and Publications

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) brings together leading centers nationwide in a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics, and to address mechanisms of treatment response, resistance, or toxicity. Here are some noteworthy moments in CPTAC history.

CPTAC Timeline and Milestones

Image as of Fall 2019

Selected publications (List as of December 2021)

Proteogenomic characterization of pancreatic ductal adenocarcinoma Cell. 2021 Sep 16;184(19):5031-5052.e26. PMID: 34534465
A proteogenomic portrait of lung squamous cell carcinoma Cell. 2021 Aug 5;184(16):4348-4371.e40. PMID: 34358469
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance Cancer Cell. 2021 Jul 12;39(7):999-1014.e8. PMID: 34171263
Proteogenomic and metabolomic characterization of human glioblastoma Cancer Cell. 2021 Apr 12;39(4):509-528.e20. PMID: 33577785
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy Cell. 2020 Nov 25;183(5):1436-1456.e31. PMID: 33212010
Proteogenomic Characterization of Endometrial Carcinoma. Cell. 2020 Feb 20;180(4):729-748.e26. PMID: 32059776
Microscaled proteogenomic methods for precision oncology Nat Commun. 2020 Jan 27;11(1):532. PMID: 31988290
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma Cell. 2019 Oct 31;179(4):964-983.e31. PMID: 31675502
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities Cell. 2019 May 2;177(4):1035-1049.e19. PMID: 31031003
Proteogenomic Characterization of Human Early-Onset Gastric Cancer Cancer Cell. 2019 Jan 14;35(1):111-124.e10. PMID: 30645970
A proposal for validation of antibodies Nat Methods. 2016 Oct;13(10):823-7. PMID: 27595404
Proteogenomics connects somatic mutations to signalling in breast cancer Nature. 2016 Jun 2;534(7605):55-62. PMID: 27251275
Proteogenomic characterization of human colon and rectal cancer Nature. 2014 Sep 18;513(7518):382-7. PMID: 25043054