Error message

  • Deprecated function: Return type of DateObject::__wakeup() should either be compatible with DateTime::__wakeup(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 143 of /local/drupal/proteomics/sites/default/modules/date/date_api/date_api.module).
  • Deprecated function: Return type of DateObject::format($format, $force = false) should either be compatible with DateTime::format(string $format): string, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 143 of /local/drupal/proteomics/sites/default/modules/date/date_api/date_api.module).
  • Deprecated function: Return type of DateObject::setTimezone($tz, $force = false) should either be compatible with DateTime::setTimezone(DateTimeZone $timezone): DateTime, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 143 of /local/drupal/proteomics/sites/default/modules/date/date_api/date_api.module).
  • Deprecated function: Optional parameter $input declared before required parameter $form_state is implicitly treated as a required parameter in include_once() (line 1439 of /local/drupal/proteomics/includes/bootstrap.inc).
  • Deprecated function: Optional parameter $input declared before required parameter $form_state is implicitly treated as a required parameter in require_once() (line 12 of /local/drupal/proteomics/sites/default/modules/media/media.module).
  • Deprecated function: Optional parameter $module_name declared before required parameter $data is implicitly treated as a required parameter in require_once() (line 18 of /local/drupal/proteomics/sites/default/modules/media/modules/media_wysiwyg/media_wysiwyg.module).
  • Deprecated function: Optional parameter $view_mode declared before required parameter $langcode is implicitly treated as a required parameter in include_once() (line 1439 of /local/drupal/proteomics/includes/bootstrap.inc).
  • Deprecated function: Optional parameter $item declared before required parameter $complete_form is implicitly treated as a required parameter in include_once() (line 1439 of /local/drupal/proteomics/includes/bootstrap.inc).
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CPTAC

Flow chart of the CPTAC pipeline.

The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics.

Launched in 2011, CPTAC pioneered the integrated proteogenomic analysis of colorectal, breast and ovarian cancer to reveal new insights into these cancer types, such as identification of proteomic-centric subtypes, prioritization of driver mutations by correlative analysis of copy number alterations and protein abundance, and understanding cancer-relevant pathways through posttranslational modifications.

CPTAC is currently leveraging its investment in cancer proteogenomics by characterizing additional cancer types, expanding its application through open-source community resources, and accelerating precision oncology by applying proteogenomics to questions of toxicity and resistance in clinical trials.  This is being achieved through a coordinated effort by CPTAC-affiliated Proteome Characterization Centers, Proteogenomic Translational Research Centers, and Proteogenomic Data Analysis Centers located throughout the country.

CPTAC’s progress in proteogenomics enabled the creation of two programs in 2016 aimed at deepening our understanding of this emerging field.  The Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) network seeks to effectively bridge oncology research and care by partnering with the health care systems of the Department of Defense and Veterans Administration to study ways to make proteogenomic analysis of a patient’s tumor part of routine cancer care.  Similarly, the International Cancer Proteogenome Consortium (ICPC) facilitates the cooperation of more than 10 countries to study commonly diagnosed cancers in their unique populations with the goal of enhancing precision oncology and sharing data collected with scientists and physicians throughout the world.

Data (genomics, proteomics, imaging), assays, and reagents are made available to the public as a Community Resource to accelerate cancer research and advance patient care.