UniProt, the leading online protein reference library, has expanded its collaboration with the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC). In addition to searching for a protein-of-interest in UniProt, which includes cross-reference links to the NCI CPTAC Assay Portal for fit-for-purpose targeted assays, users now have cross-reference links to the NCI CPTAC Antibody Portal for cancer-associated renewable antibodies.
The CPTAC Assay Portal is a public resource of fit-for-purpose quantitative mass spectrometry-based proteomic targeted assays, with the CPTAC Antibody Portal providing access to a large number of standardized renewable affinity reagents (to cancer-associated targets) and accompanying characterization data. Both portals support the National Institutes of Health’s Rigor and Reproducibility Principles and Guidelines.
Since 2002, UniProt (a collaboration between the European Bioinformatics Institute, the Swiss Institute of Bioinformatics, and the Protein Information Resource) has aimed to provide the scientific community with a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information, and since 2011, CPTAC has strived to enhance the understanding of the molecular mechanisms of cancer through integrated proteomic and genomic analysis, generate community resources (proteogenomic datasets, medical images, assays, and reagents), and accelerate the translation of molecular findings into the clinic. With well over 1,600 resources within UniProt-CPTAC cross-references, teaming up allows UniProt and CPTAC to fulfill these core missions.
Researchers can find CPTAC data in the search results under ‘Proteomic Databases’, or by using the search term ‘CPTAC’.