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OCCPR: A Leader in Cancer Proteomics and Proteogenomics

The mission of the NCI’s Office of Cancer Clinical Proteomics Research (OCCPR) is to improve prevention, early detection, diagnosis, and treatment of cancer by enhancing the understanding of the molecular mechanisms of cancer, advance proteome and proteogenome science and technology development through community resources (data and reagent), and accelerate the translation of molecular findings into the clinic. This is achieved through OCCPR-supported programs such as the Clinical Proteomic Tumor Analysis Consortium (CPTAC), partnerships with Federal agencies, and collaborations with international organizations/institutions.

The International Cancer Proteogenome Consortium

International Cancer Proteogenome Consortium

Learn about ICPC and how the consortium is breaking down silos to advance proteogenomic cancer research worldwide.

News and Announcements

March 27, 2020
OCCPR Webinar: Network Exploration Tool for Cancer Research

Finding novel interactions from comprehensive genomics and proteomics (mass spectrometry generated) is made significantly easier with the help of a visual, interactive guide. Researchers from the Mount Sinai Protogenomic Data Analysis Center (PGDAC) team within the Clinical Proteomics Tumor Analysis...
March 23, 2020
The Proteomic Data Commons Is Now Live!

NCI announces the launch of the NCI Proteomic Data Commons (PDC)! The PDC is a next-generation proteomics data repository within NCI’s Cancer Research Data Commons with corresponding genomics and imaging data sets to enable data access, analysis, and sharing for integrative research.
March 17, 2020
New CPTAC Imaging Data Available

New histopathology slides available from CPTAC lung squamous cell carcinoma, lung adenocarcinoma and glioblastoma multiforme studies. 149 images from 28 new cases added in the month of February 2020 are publicly available on the TCIA CPTAC Pathology Portal!
March 10, 2020
Making Space for Ubiquitin Proteomics

Protein ubiquitylation is best known for its role in degradation, leading molecules to the cell’s recycle bin, but it also has roles in cellular processing and protein interactions. Unfortunately, research using proteomic techniques have been limited due to experimental and technical complications...
March 4, 2020
OCCPR Webinar: The Cancer Imaging Archive

The Cancer Imaging Archive (TCIA) houses radiology and histopathology data for the CPTAC Program. There are over 1500 cases and with more than 6000 images…and counting…of 10 cancer types freely available for the public to view. Each case has complementary proteomic data through the Proteomic Data...
February 13, 2020
New, Detailed Molecular Roadmap Boosts Fight Against Endometrial Cancer

A study published Feb 13th in Cell provides an unprecedented look at the dozens of molecular steps that occur to bring about endometrial cancer, commonly known as uterine cancer. The study offers insights about how physicians might be able to better identify which patients will need aggressive...
January 29, 2020
CPTAC Survey Results Show Success

The Office of Cancer Clinical Proteomics Research (OCCPR) cares what you think about the Clinical Proteomic Tumor Analysis Consortium (CPTAC) program and all its offerings! Working with Clarivate Analytics to conduct a survey, we wanted to determine the effect of the CPTAC program on the...
January 29, 2020
New CPTAC Histopathology Imaging Data Ready to View

The addition of 367 new pathology slides and 51 new pathology subjects for lung squamous cell carcinoma is now available on the TCIA CPTAC Pathology Portal. Additional imaging data is also available for 10 cancer types including cutaneous melanoma, clear cell renal cell carcinoma, head & neck...
January 28, 2020
OCCPR Webinar: Heatmap Visualization Tool for Cancer Research

Visualizing gene and protein expression from comprehensive genomics and proteomics (mass spectrometry generated) data is beneficial for researchers but often difficult to achieve. Researchers from the Mount Sinai PGDAC team within the CPTAC program have developed a new interactive data tool to query...
January 27, 2020
Micro-Scaled Method Holds Promise as Improved Cancer Diagnostic Platform

Using a single-needle biopsy and new technology for tumor diagnosis developed by Baylor College of Medicine and the Broad Institute of MIT and Harvard, researchers have been able to provide a more detailed and wider window into cancer biology, tumor type and the mechanisms of response and resistance...

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