Hepatocellular carcinoma (HCC), the most common form of liver cancer, occurs most often in people with hepatitis B or C viral (HBV or HCV) infections who drink large amounts of alcohol.  Unlike the recent progress of antiviral-eliminating therapy for HCV, current antiviral therapy is only able to reduce rather than eliminate HBV and is estimated to affect 292 million peop

UniProt, the leading online protein reference library, has teamed up with CPTAC!  Now, search results for your protein-of-interest will include links to the CPTAC Assay Portal for relevant peptides and assay protocols, while giving CPTAC users all the rich functional annotation in UniProt!  

RAS gene mutations and their pathways have  stymied cancer researchers for decades.  RAS-driven cancers make up more than 30% of all human cancers due to their association with uncontrollable cell growth, death-signal evasion, and drug resistance.  In 2014, the National Cancer Institu

Genomics platform cBioPortal offers a “biologist-friendly” resource for querying mutations, copy number variations and gene expression. It contains data from The Cancer Genome Atlas (TCGA) which includes proteomics data in the form of arrays that use antibodies to track protein levels. CPTAC mass spectrometry-based proteomics, however, has more information than the arrays provide.

The Journal of Molecular & Cellular Proteomics has released a special issue this month (August 2019) on Multi-Omics Integration.  The issue sets out to show how multi-omics research is integral to the understanding of biological systems.  It touts work from several of our CPTAC investigators who share their

New assays have been released today!  CPTAC and researchers from the University of Victoria – Genome British Columbia Proteomics Centre just released over 130 quantitative, fit-for-purpose, multiplexed mouse multiple reaction monitoring (MRM) mass spectrometry (MS)-based  plasma assays for public use on NCI’s Proteomic (CPTAC) Assay Portal. 

CPTAC researchers at John Hopkins University School of Medicine have developed a technique to reliably identify o-linked glycosylation sites and site-specific glycans with core 1 structures.  Before you dust off

Proteomic profiling often entails using a large sample input to explore the dynamic nature of protein expression and regulation. However, there are instances when researchers have the opposite due to prior methodology such as fluorescence activated cell sorting (FACS) or when dealing with patient samples.

June 13th, 2019 marked the addition of our 33rd institution to the International Cancer Proteogenomic Consortium (ICPC).  We are pleased to include Amsterdam UMC as a participant in the global effort to accelerate cancer research.

The National Cancer Center - Korea (NCC-K) joins the International Cancer Proteogenome Consortium (ICPC) global partnership.  The NCC-K has joined the ranks of 31 institutions in 12 countries around the world that have previously made this commitment with the